Systems and methods for performing calibration of antenna arrays with dual-polarization antenna elements are disclosed. An example system includes an antenna array and a calibration circuitry. The antenna array includes a plurality of antenna cells arranged in K rows and L columns, each cell including a plurality of dual-polarization antenna elements. Antenna cells in columns 1 through Y form a first sub-array, while antenna cells in columns Y+1 through L form a second sub-array. The calibration circuitry is configured to perform calibration by individually calibrating each column of antenna cells of the first sub-array, calibrating different columns of antenna cells of the first sub-array with respect to one another, individually calibrating each column of antenna cells of the second sub-array, calibrating different columns of antenna cells of the second sub-array with respect to one another, and calibrating antenna elements of the first and second sub-arrays with respect to one another.