A system includes a processor and, a computer-readable tangible storage device storing program instructions for execution by the processor. The program instructions include instructions for receiving ultrasonic derived data comprising an ultrasound image, representing a region of interest, and radio frequency “(RF”) data associated with the ultrasound image, and instructions for analyzing the RF data to identify at least one feature associated with a region of interest, including either or both of a feature representing a two-dimensional spectrum feature and a feature based on a cepstrum determined from the RF data. The program instructions further include instructions for classifying the region of interest as one of a plurality of anatomical classes from the identified at least one feature and causing a display to display the anatomical class.