There are provided a lighting control method, system, and device for an NVME backboard, and a medium. The method is applied to a mainboard. The method includes: executing a target code for parsing a target VPP signal upon reception of the target VPP signal, where the target code is added in the mainboard in advance and stores VPP addresses respectively corresponding to NVME backboards connected with the mainboard; parsing the target VPP signal to obtain a target VPP address corresponding to the target VPP signal; and delivering the target VPP address to a target NVME backboard corresponding to the target VPP address to light the target NVME backboard.