Invention Grant
- Patent Title: Long chain dibasic acid with low content of long chain dibasic acid impurity of shorter carbon-chain and preparation method thereof
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Application No.: US16503309Application Date: 2019-07-03
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Publication No.: US11434510B2Publication Date: 2022-09-06
- Inventor: Wenbo Liu , Min Xu , Chen Yang , Howard Chou , Xiucai Liu
- Applicant: Cathay Biotech Inc. , CIBT America Inc.
- Applicant Address: CN Shanghai; US DE Newark
- Assignee: Cathay Biotech Inc.,CIBT America Inc.
- Current Assignee: Cathay Biotech Inc.,CIBT America Inc.
- Current Assignee Address: CN Shanghai; US DE Newark
- Agency: Adsero IP
- Main IPC: C12P7/44
- IPC: C12P7/44 ; C12N15/52 ; C12N9/02 ; C12N15/01 ; C12P7/6409
Abstract:
The present invention relates to a long-chain dibasic acid with low content of long-chain dibasic acid impurity of shorter carbon chain, to the preparation of a long-chain dibasic acid producing strain by directed evolution of POX gene and homologous recombination, and to the production of a long-chain dibasic acid with low content of long-chain dibasic acid impurity of shorter carbon chain by using the strain. The present invention also relates to a strain containing a mutated promoter, wherein, when a long-chain dibasic acid is produced by fermentation of this strain, the content of the acid impurity of shorter carbon chain in the fermentation product is significantly reduced.
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