Invention Grant
- Patent Title: Recombinant influenza virus-like particles (VLPS) produced in transgenic plants
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Application No.: US16219306Application Date: 2018-12-13
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Publication No.: US11434497B2Publication Date: 2022-09-06
- Inventor: Marc-Andre D'Aoust , Manon Couture , Frederic Ors , Sonia Trepanier , Pierre-Olivier Lavoie , Michele Dargis , Louis-Philippe Vezina , Nathalie Landry
- Applicant: Medicago Inc.
- Applicant Address: CA Quebec
- Assignee: Medicago Inc.
- Current Assignee: Medicago Inc.
- Current Assignee Address: CA Quebec
- Agency: ArentFox Schiff LLP
- Priority: CACA2615372 20080121
- Main IPC: C12N15/82
- IPC: C12N15/82 ; A61K39/145 ; C07K14/005 ; C12N7/00 ; C12N9/90 ; A61K39/12 ; G06F9/50 ; A61K39/00
Abstract:
A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plant lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
Public/Granted literature
- US20190177739A1 RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS Public/Granted day:2019-06-13
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