Invention Grant
- Patent Title: Optimized Zika virus envelope gene and expression thereof
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Application No.: US16320983Application Date: 2017-07-26
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Publication No.: US11434261B2Publication Date: 2022-09-06
- Inventor: David E. Clements
- Applicant: Hawaii Biotech Inc.
- Applicant Address: US HI Honolulu
- Assignee: Hawaii Biotech Inc.
- Current Assignee: Hawaii Biotech Inc.
- Current Assignee Address: US HI Honolulu
- Agency: DLA Piper LLP (US)
- International Application: PCT/US2017/044008 WO 20170726
- International Announcement: WO2018/022790 WO 20180201
- Main IPC: C07K14/005
- IPC: C07K14/005 ; A61P31/14 ; A61K39/12 ; A61K39/39 ; C12N15/85 ; A61K39/00
Abstract:
The present invention is directed to the expression and secretion the Zika virus envelope protein. Elements of the pre-membrane and envelope sequence have been modified to enhance the expression of the envelope protein as a secreted product in the culture medium of transformed insect cell lines. The expressed and purified product is suitable as a vaccine antigen.
Public/Granted literature
- US20210332084A1 OPTIMIZED ZIKA VIRUS ENVELOPE GENE AND EXPRESSION THEREOF Public/Granted day:2021-10-28
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