Infusion pump alignment features for vertically-oriented IV tubes are disclosed. In an example, an infusion pump housing includes a tube channel having a radial curvature for bending an IV tube from a horizontal orientation to a vertical orientation when the infusion pump is positioned for operation. The housing also includes a hood having a first side and a second side that are divided by the tube channel. The infusion pump has a door that is connected to the housing for enclosing the tube channel and the hood. The door includes a cavity having dimensions to receive the hood when the door is in a closed position. The hood is configured to engage the cavity to prevent the door from closing if the IV tube is not positioned along the tube channel.