A quantum processing system may include one or more superconducting qubits and a qubit controller for controlling the one or more qubits. The qubit controller includes a radio frequency generation unit comprising electronic components, which are altogether configured to generate modulated RF signals. The controller also includes a phase locked loop unit maintaining a reference clock for two or more of the components of the RF generation unit, and a timing controller including an absolute timing register, the latter accessed by the reference clock, in operation. The qubit controller comprises a sequencer coupled to the timing controller to synchronize said two or more of said components by maintaining a coherent signal for said two or more of said components, the coherent signal phase matched to the one or more qubits, to drive and/or read out the one or more qubits via modulated signals generated by the synchronized components, in operation.