In example embodiments, systems and methods extract a model of a computer application during load time and store the model in memory. Embodiments may insert instructions into the computer application at run time to collect runtime state of the application, and analyze the collected data against the stored model to perform detection of security events. Embodiments may also instrument an exception handler to detect the security events based on unhandled memory access violations. Embodiments may, based upon the detection of the security events, dynamically respond, such as by modify a computer routine associated with an active process of the computer application. Modification may include installing or verifying an individual patch in memory associated with the computer application.