System-aware radio frequency (RF) front ends for wireless communication systems are provided. High complexity communication systems, such as Third Generation Partnership Project (3GPP) fifth generation (5G)-new radio (NR) systems, impose severe board area, volume, thermal and interference penalties on wireless devices. In the case of 5G-NR, this is due to the number of bands to be supported, the instantaneous bandwidth and spectral efficiency among other parameters. Other communications systems can involve high modulation of other parameters that similarly impose such penalties. Embodiments described herein provide a co-designed RF front end architecture that utilizes system knowledge (e.g., from baseband or other digital control circuitry, from antenna feedback, etc.) to dynamically adjust the parameters of various RF front-end components. System-aware RF front ends are thus able to improve and optimize performance criteria (e.g., to reduce the above penalties in complex communications systems).