A potentiostat circuit for controlling a work electrode voltage and for measuring a work electrode current is disclosed. The disclosed potentiostat circuit implementations have a topology and include elements to provide a plurality of benefits. The plurality of benefits includes an enlarged range of controllable work electrode voltages and bidirectional work electrode current measurements, high immunity from temperatures variations and process mismatch. The disclosed potentiostat circuit implementations can be used in applications requiring accuracy, low power consumption, and small size. The applications can include portable and/or multichannel electrochemical applications.