A system and method of image processing including a processor in communication with a display and a computer readable recording medium having instructions executed by the processor to read an image data set from the memory, segment the image data set, and skeletonize the segmented image data set. The instructions cause the processor to graph the skeletonized image data set, assign a branch identification (ID) for each branch in the graph, and associate each voxel of the segmented image data set with a branch ID. The instructions cause the processor to generate a three-dimensional (3D) mesh model from the graphed skeletonized image data set, associate each vertex of the 3D mesh model with a branch ID; and display in a user interface the 3D mesh model, and an image of the image data set.