A drug dispensing system includes fulfillment stations that are each characterized by a set of dispensary attributes. The fulfillment stations each, in response to receiving a first order message including a first unique drug identifier, fill a container with pills matching the first unique drug identifier. A routing determination module, for each order message corresponding to a prescription order, selects one of the fulfillment stations based on compatibility between dispensary attributes for the selected fulfillment station and dispensation preferences related to the order message and transmits the order message to the selected fulfillment station. An order status subsystem conditionally sends a cancellation instruction relating to one of the order messages to the respective fulfillment station to cancel dispensing of pills. Each fulfillment station is configured to, in response to receiving a first cancellation instruction indicating a specified order message, terminate dispensing of pills corresponding to the specified order message.