Invention Grant
- Patent Title: Benzothia(di)azepine compounds and their use as bile acid modulators
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Application No.: US17502958Application Date: 2021-10-15
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Publication No.: US11377429B2Publication Date: 2022-07-05
- Inventor: Per-Göran Gillberg , Ingemar Starke , Santosh S. Kulkarni
- Applicant: Albireo AB
- Applicant Address: SE Gothenburg
- Assignee: Albireo AB
- Current Assignee: Albireo AB
- Current Assignee Address: SE Gothenburg
- Agency: Fish & Richardson P.C.
- Priority: IN202011033169 20200803
- Main IPC: C07D281/02
- IPC: C07D281/02 ; C07D281/10 ; C07D285/36 ; A61K31/55 ; A61K31/554 ; A61P1/00 ; A61P3/00 ; A61P9/00
Abstract:
The invention relates to certain 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives as defined herein. These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.
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