A display substrate and a method for manufacturing the same, a display panel and a display device are provided. The display substrate includes a base substrate, a display component on the base substrate, and an encapsulation layer covering the display component, where the encapsulation layer includes an organic layer and an inorganic layer that are stacked alternately. A detection capacitor is further provided in a peripheral region of the display substrate. The detection capacitor includes a first electrode plate on a side of the encapsulation layer close to the base substrate, and a second electrode plate on a side of the encapsulation layer away from the base substrate.