An example method facilitates Global Traffic Management (GTM) and associated selective distribution of computing loads and/or network traffic among different geographically distributed data centers of a particular domain by allocating the servicing of request messages from Local Domain Name Servers (LDNSs) to data centers that are estimated to provide the quickest response times to the LDNSs. Estimates of path latencies or Round Trip Times (RTTs) between the LDNSs and the different distributed data centers are estimated using DNS reflection methodologies and are maintained in a database that may be accessed and collectively managed via the data centers, e.g., via use of a web service that fronts the database. Locations of the LDNSs approximate locations of client devices seeking access to the domain.