An information processing system includes: a first information processing device that transmits first data to be retained via a communication path; a second information processing device that calculates first calculation result data that is a calculation result of the first data received via the communication path and second data to be retained and transmits the calculated first calculation result data via the communication path; a third information processing device that transmits third data to be retained via the communication path; and a fourth information processing device that calculates second calculation result data that is a calculation result of the third data received via the communication path and fourth data to be retained and calculates third calculation result data that is a calculation result of the first calculation result data received via the communication path and the calculated second calculation result data.