A rapid shutdown device capable of driving two MOSFETs connected in series through single drive signal, which includes a switch S1, a switch S2, a control IC and a drive circuit. The PV+ terminal of the photovoltaic module is connected to an output terminal OUT+ through the switch S1 and the switch S2 connected in series in sequence. The PV− terminal of the photovoltaic module is connected to an output terminal OUT−. The control IC, the switch S1 and the switch S2 are connected with the drive circuit respectively, and the two signal terminals of the control IC control the on-off of switch S1 and switch S2 through the drive circuit. The invention adopts two switches connected in series for on-off operation, greatly improving the shutoff reliability and safety of the photovoltaic power generation system.