A method is for determining orthogonal slice image data sets of a tomosynthesis recording of an examination region. In an embodiment, the method includes recording a tomosynthesis recording and reconstructing a plurality of first slice image data sets in a first plane based upon the tomosynthesis recording; selecting a first slice image data set from the plurality of first slice image data sets; marking a microcalcification or a region of interest with a punctiform marking in the first slice image data set selected; and determining, from a second slice image data set in a second plane orthogonal to the first plane, and from a third slice image data set in a third plane orthogonal to the first plane and the second plane, wherein a point of intersection of the first plane, the second plane and the third plane includes the punctiform marking.