Provided are systems and processes for optimizing assignments of deliveries for perishable goods. In one aspect, a method is provided for pairing a set of created orders with a set of available couriers. The set of created orders may include orders confirmed by the merchant and the set of available couriers include couriers that are online with an active status. Feasible pairings are generated between each courier and each created order. Infeasible pairings are eliminated based on factors such as transportation mode. Possible routes for each pairing are generated and scored based on weighted factors. The scores are optimized to achieve a set of routes with a maximum score. The routes are then offered to the corresponding courier if the courier will arrive at or after the created order is completed by the merchant. A neural network may be implemented to recognize the optimal score for a given duration.