Methods and apparatus are provided for managing code block interleaving and de-interleaving in wireless communication systems. A transmitter detects one or more conditions related to transmissions to be made from the transmitter and decides, based on the detection, to disable an interleaver while processing the transmissions, the interleaver used to spread code blocks over available resources. A receiver detects one or more conditions relating to the transmissions from the transmitter and determines, based on the detection, whether an interleaver was used at the transmitter while processing the transmissions. The receiver decides whether or not to de-interleave code blocks of the received transmission based on the determination.