A central signal segregation station (100) employs a signal acquisition controller (103) and a signal segregation controller (104). In operation, the signal acquisition controller (103) receives a plurality of different types of physiological signals from a plurality of unknown physiological sensors (10; 20; 30; 40; 50; 60; 70; 80). For a monitoring of the physiological signals, the signal segregation controller (104) identifies a particular type of each physiological signal based on distinct signal features of each physiological signal corresponding to a different physiological signal model (101) among a plurality of physiological signal models (101) derived from known types of physiological sensors. For analyzing the physiological signals, the station (100) may further employ a signal analyzing controller (105) executing signal quality processing of the physiological signals, providing signal-specific feedback to any physiological sensor(s) communicating low quality physiological signal(s), annotating specific regions of each physiological signal having maximum diagnostic information and/or performing a confirmatory diagnosis of the physiological signals.