Calibration based on twist and orientation for towed object can include determining an amount of twist as a function of length of a portion of a towed object based on output of tilt sensors in the portion of the towed object and a model that describes the twist along the portion of the towed object. An orientation of a seismic sensor can be determined based on the determined amount of twist and a position of the seismic sensor along a length of the portion of the towed object. The seismic sensor can be calibrated based on the orientation.