Invention Grant
- Patent Title: Compositions and methods for the treatment of HER2-expressing solid tumors
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Application No.: US15771932Application Date: 2016-10-31
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Publication No.: US11266726B2Publication Date: 2022-03-08
- Inventor: Lauren V. Wood , Brenda D. Roberson , Jay A. Berzofsky , John C. Morris , Jason C. Steel , Masaki Terabe , Malcolm K. Brenner
- Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services , Baylor College of Medicine
- Applicant Address: US MD Bethesda; US TX Houston
- Assignee: The U.S.A., as represented by the Secretary, Department of Health and Human Services,Baylor College of Medicine
- Current Assignee: The U.S.A., as represented by the Secretary, Department of Health and Human Services,Baylor College of Medicine
- Current Assignee Address: US MD Bethesda; US TX Houston
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2016/059680 WO 20161031
- International Announcement: WO2017/075570 WO 20170504
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61P35/00 ; A61K35/761
Abstract:
Recombinant adenoviruses expressing the extracellular (EC) and transmembrane (TM) domains of human HER2 (HER2ECTM) are described. The recombinant adenoviruses express a chimeric fiber protein having the adenovirus type 35 (Ad5) shaft and knob domains, which facilitates transduction of human dendritic cells by the recombinant HER2ECTM expressing adenovirus. Compositions that include dendritic cells transduced by the recombinant adenovirus and their use for treating HER-positive tumors is described.
Public/Granted literature
- US20180344828A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF HER2-EXPRESSING SOLID TUMORS Public/Granted day:2018-12-06
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