Invention Grant
- Patent Title: Single-chain antibody specifically binding MG7, highly glycosylated CEA and use thereof in detection and therapy
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Application No.: US16321529Application Date: 2017-07-27
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Publication No.: US11266688B2Publication Date: 2022-03-08
- Inventor: Daiming Fan , Yongzhan Nie , Kaichun Wu , Yueqiong Cao , Jijun Yuan , Xuejun Yu
- Applicant: THE FOURTH MILITARY MEDICAL UNIVERSITY , SHANGHAI GENBASE BIOTECH CO., LTD.
- Applicant Address: CN Shaanxi; CN Shanghai
- Assignee: THE FOURTH MILITARY MEDICAL UNIVERSITY,SHANGHAI GENBASE BIOTECH CO., LTD.
- Current Assignee: THE FOURTH MILITARY MEDICAL UNIVERSITY,SHANGHAI GENBASE BIOTECH CO., LTD.
- Current Assignee Address: CN Shaanxi; CN Shanghai
- Agency: Baker, Donelson, Bearman, Caldwell & Berkowitz PC
- Agent Robin L. Teskin
- Priority: CN201610614701.3 20160729
- International Application: PCT/CN2017/094755 WO 20170727
- International Announcement: WO2018/019275 WO 20180201
- Main IPC: C07K16/30
- IPC: C07K16/30 ; A61P35/00 ; C07K19/00 ; A61K35/17 ; C12N15/62 ; G01N33/574 ; C12N5/10 ; C07K16/40
Abstract:
The present invention provides a glycosylated CEA-specific single-chain antibody, and a chimeric antigen receptor (CAR) targeting a glycosylated CEA, which can be used in manufacture of an agent or a medicament for diagnosis or treatment of a tumor overexpressing glycosylated CEA.
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