Invention Grant
- Patent Title: Method for increasing cell proliferation in pancreatic beta cells, treatment method, and composition
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Application No.: US16344230Application Date: 2017-10-26
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Publication No.: US11266647B2Publication Date: 2022-03-08
- Inventor: Andrew F. Stewart , Peng Wang
- Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Applicant Address: US NY New York
- Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee Address: US NY New York
- Agency: Troutman Pepper Hamilton Sanders LLP (Rochester)
- International Application: PCT/US2017/058498 WO 20171026
- International Announcement: WO2018/081401 WO 20180503
- Main IPC: A61K31/47
- IPC: A61K31/47 ; A61K31/44 ; A61K31/425 ; A61K31/40 ; A61K31/519 ; A61P1/18 ; A61P3/10 ; A61K31/4045 ; A61K31/428 ; A61K31/437 ; A61K31/454 ; A61K31/4709 ; C12N5/071
Abstract:
The present invention relates to a method of increasing cell proliferation in a population of pancreatic beta cells and a method of treating a subject for a condition associated with an insufficient level of insulin secretion. Also disclosed is a composition. The composition includes a dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1 A) inhibitor and a transforming growth factor beta (TGFP) superfamily signaling pathway inhibitor.
Public/Granted literature
- US20190328738A1 METHOD FOR INCREASING CELL PROLIFERATION IN PANCREATIC BETA CELLS, TREATMENT METHOD, AND COMPOSITION Public/Granted day:2019-10-31
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