Invention Grant
- Patent Title: Polycyclic compound acting as IDO inhibitor and/or IDO-HDAC dual inhibitor
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Application No.: US16649455Application Date: 2018-09-20
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Publication No.: US11266640B2Publication Date: 2022-03-08
- Inventor: Hancheng Zhang , Xiangyang Ye
- Applicant: Hangzhou Innogate Pharma Co., Ltd.
- Applicant Address: CN Zhejiang
- Assignee: Hangzhou Innogate Pharma Co., Ltd.
- Current Assignee: Hangzhou Innogate Pharma Co., Ltd.
- Current Assignee Address: CN Zhejiang
- Agency: Ice Miller LLP
- Priority: CN201710854520.2 20170920,CN201711397888.7 20171221,CN201810119324.5 20180206
- International Application: PCT/CN2018/106768 WO 20180920
- International Announcement: WO2019/057123 WO 20190328
- Main IPC: A61K31/4709
- IPC: A61K31/4709 ; A61K31/47 ; A61K31/501 ; A61K31/506 ; A61K31/5383 ; A61K39/395 ; C07D215/14 ; C07D401/12 ; C07D401/14 ; C07D405/12 ; C07D417/12 ; C07D498/04

Abstract:
Compounds as IDO inhibitors and/or dual inhibitors of IDO-HDAC are described. Specifically, the compounds represented by the following formula (I) are described, wherein each group is defined as described in the specification. The compounds have IDO inhibitory activity or IDO-HDAC dual inhibitory activity and can be used for preventing or treating diseases associated with IDO and/or IDO-HDAC activity or expression levels. At the same time, the compounds of the present invention can be combined with an anti-tumor antibody such as PD-1 and PD-L1, and such a combination can greatly increase the anti-tumor response rate of the antibody and broaden the types of tumors to be treated.
Public/Granted literature
- US20200276180A1 POLYCYCLIC COMPOUND ACTING AS IDO INHIBITOR AND/OR IDO-HDAC DUAL INHIBITOR Public/Granted day:2020-09-03
Information query
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