Devices, systems, and methods to treat hypertension. In at least one embodiment of a method of the present disclosure, the method comprises the step of obtaining data indicative of a renal artery of a patient with hypertension; and if the data indicates that the renal artery is stiff, relatively stiff, noncompliant, or relatively noncompliant, the method further comprises the step of performing a renal ablation procedure on the renal artery to treat the hypertension.