A method of closed-loop power control for a user equipment (UE) in multi-panel transmission is disclosed. The method comprises receiving a transmission power control (TPC) command indicating at least a power control adjust value carried by downlink control information (DCI), obtaining antenna panel information for identifying a characteristic of one of a plurality of antenna panels of the UE, and applying the power control adjust value to at least one antenna panel for physical uplink (UL) shared channel (PUSCH)/physical UL control channel (PUCCH) transmission according to the obtained antenna panel information.