Example methods for communicating based on route prediction and pre-preparation in a wireless network are provided. One example method includes determining, by a network entity, a predicted time of entering and a predicted duration of stay of a user equipment (UE) in each cell of a plurality of cells according to a predicted route of the UE, the predicted route including predicted UE locations at corresponding predicted times. The network entity can then determine mobility prediction information according to the predicted time of entering and the predicted duration of stay of the UE in each cell of the plurality of cells. The network entity can then transmit the mobility prediction information to the UE.