Described are systems and methods for generating high dynamic range (“HDR”) images based on image data obtained from different image sensors for use in detecting events and monitoring inventory within a materials handling facility. The different image sensors may be aligned and calibrated and the image data from the sensors may be generated at approximately the same time but at different exposures. The image data may then be preprocessed, matched, aligned, and blended to produce an HDR image that does not include overexposed regions or underexposed regions.