A method for operating an energy storage system, which includes at least one energy store with a plurality of cells and is designed to supply an electric drive system of a vehicle is provided. The method includes identifying a reference cell from among the cells, and carrying out a first symmetrization procedure for the cells at a first point in time, at which the reference cell has a first reference charge state. The method also includes carrying out a second symmetrization procedure for the cells, if the following conditions a) and b) are met at a second point in time following the first point in time: a) the voltage difference between the voltage of the cell with the lowest voltage and the voltage of the cell with the highest voltage is greater than or equal to a specified voltage difference; and b) the reference state of charge of the reference cell at the second point in time lies within a specified state of charge range, the state of charge range being determined in such a way that it includes the first reference state of charge.