Screening of entities using multi-level rules and tolerances against entity data. The entity data are screened for multiple entities, including determining if the entity data comply with business activity rules. If a respective entity fails to comply with the business activity rules, investments with the non-compliant entity are added to a list of non-usable investments. If the respective entity complies with the business activity rules, the respective entity is identified as a business-activity-compliant entity. Each respective business-activity-compliant entity is then screened using multiple screening methodologies, which are applied to screen the entity data for the respective business-activity-compliant entity against each of the financial rules in accordance with the respective screening methodology. If the financial rules satisfy at least one tolerance setting, investments with the respective business-activity-compliant entity are added to a list of usable investments; otherwise, investments with the respective business-activity-compliant entity are added to the list of non-usable investments.