The present disclosure discloses a method for managing e-notes of electronic books and an electronic device. The method includes: acquiring content data of an e-note when the e-note is generated for the electronic book; storing the content data of the e-note into an e-note file corresponding to the electronic book; in response to receiving an e-note management instruction, identifying the electronic book corresponding to the e-note management instruction, acquiring and displaying the e-note file corresponding to the electronic book, and managing the e-note based on the e-note file corresponding to the electronic book.