Embodiments include disposable sensor elements, systems including the same and related methods. In an embodiment, a disposable sensor element is included having a substrate and a first measurement zone comprising a plurality of discrete binding detectors. The first measurement zone can define a portion of a first gas flow path. In some embodiments the disposable sensor element can further include a second measurement zone, separate from the first measurement zone. The second measurement zone can include a plurality of discrete binding detectors. The second measurement zone can be disposed outside of the first gas flow path. Other embodiments are also included herein.