Invention Grant
- Patent Title: Cell-based assays for detection of antibodies or other factors that neutralize uptake of lysosomal enzymes
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Application No.: US15773822Application Date: 2016-11-07
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Publication No.: US11262348B2Publication Date: 2022-03-01
- Inventor: Andrew Melton , Stephen Zoog , Lynne Jesaitis
- Applicant: BIOMARIN PHARMACEUTICAL INC.
- Applicant Address: US CA Novato
- Assignee: BIOMARIN PHARMACEUTICAL INC.
- Current Assignee: BIOMARIN PHARMACEUTICAL INC.
- Current Assignee Address: US CA Novato
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/US2016/060795 WO 20161107
- International Announcement: WO2017/079729 WO 20170511
- Main IPC: G01N33/573
- IPC: G01N33/573 ; G01N33/50 ; C12N5/0783 ; G01N33/49 ; G01N33/533 ; G01N33/543 ; G01N33/68
Abstract:
The present invention relates to cell-based methods for screening body fluids or tissues for factors that prevent cellular uptake of lysosomal enzymes, including neutralizing factors such as neutralizing antibodies, that arise as a result of lysosomal enzyme replacement therapy.
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