A tracking and guidance arrangement for a surgical robot system and related method are provided. The arrangement includes a patient-interacting device including an instrument engaged a distal end of a guide arm and a fiducial marker coupled to maxillofacial anatomy of the patient. A detector is connected to an articulating arm and co-operable therewith to be positioned adjacent to the fiducial marker, with the detector being configured to interact with the fiducial marker. A controller device is configured to receive data from the detector relative to the interaction thereof with the fiducial marker, to determine a spatial relation between the fiducial marker and the detector based on the data, to determine a spatial relation of the instrument relative to the fiducial marker, and to direct the instrument to interact with the maxillofacial anatomy of the patient according to the determined spatial relations.