Embodiments relate to personalized low latency communications. A method may include receiving a description of content of a message, receiving recipient data corresponding to at least two possible recipients within a population of possible recipients, and selecting a relevant subpopulation of the population. The selecting may include, for each of the at least two possible recipients, ranking a strength of an indirect relationship between the description and the recipient data. The indirect relationship may be based on the description, the recipient data and at least one additional data source. The selecting may also include, for each of the at least two possible recipients, adding a possible recipient to the relevant subpopulation based on the ranking of the indirect relationship associated with the possible recipient. The method may further include initiating a two-way communication channel between a sender of the message and the relevant subpopulation.