The disclosure provides a method and a device in a User Equipment (UE) and a base station for wireless communication. A first node generates a first bit block, performs channel coding and then transmits a first radio signal. The first bit block comprising all bits in a second bit block and all bits in a third bit block is used for an input of the channel coding, and an output of the channel coding is used for generating the first radio signal. A Cyclic Redundancy Check (CRC) bit block of a fourth bit block is used for generating the third bit block. The fourth bit block comprises all bits in the second bit block and all bits in a fifth bit block, the bits in the fifth bit block are of fixed values, and the fifth bit block is composed of K bits, the K being a positive integer.