The present disclosure provides a display substrate, a display device, a mobile terminal, and a fabricating method of a display substrate. The display substrate includes a bending region and a non-bending region adjacent to the bending region. At least a portion of the non-bending region is provided with an inorganic layer, and at least a portion of the bending region is provided with a flexible filling layer. The display substrate further includes a stretching structure layer disposed in the bending region, and the stretching structure layer and the flexible filling layer are alternately distributed.