A systems for optimizing a user interface includes a host service/device coupled to two databases. One database stores historical information of user interaction(s) with the interface and the another stores predefined query strings that when submitted to the first database obtain statistically testable datasets. As a result of this construction, a user of the optimization system is able to submit a request to the host service/device that includes (1) a selected user interface variation and (2) a selected user interaction goal. In response, the optimization system accesses the second database to retrieve a set of queries related to the variation and a set of queries related to the goal. Thereafter, the query sets can be submitted to the first database to obtain two testable datasets (e.g., a control set and a variant set) for automatic statistical analysis.