Methods and systems for detection in an industrial internet of things data collection environment with intelligent data collection and equipment package adjustment for a production line are disclosed. An example system includes a data collector communicatively coupled to a plurality of input channels connected to data collection points operatively coupled to at least one piece of equipment of an equipment package of the production environment and a data acquisition circuit structured to interpret a plurality of detection values from the plurality of input channels. A data analysis circuit utilizes an expert system diagnostic tool to identify an off-nominal process state in response to the plurality of detection values and a response circuit adjusts an equipment package parameter in response to the off-nominal process state.