A sealing wedge-lock washer assembly usable in a hygienic, secure fastening system. A wedge-lock washer assembly comprises two wedge-lock components—one of which is a sealing wedge-lock washer having a wedge-lock cam and a sealing material bonded to its outer rim. The other component is a standard wedge-lock washer or a bolt whose head has a wedge-lock cam that engages the complementary cam on the sealing wedge-lock washer. The resulting sealing wedge-lock washer assembly locks a bolt in a secure joint that is hygienically sealed from the intrusion of contaminants by the sealing material.