Invention Grant
- Patent Title: Methods to determine tumor gene copy number by analysis of cell-free DNA
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Application No.: US16737819Application Date: 2020-01-08
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Publication No.: US11242569B2Publication Date: 2022-02-08
- Inventor: Helmy Eltoukhy , AmirAli Talasaz , Darya Chudova , Diana Abdueva
- Applicant: GUARDANT HEALTH, INC.
- Applicant Address: US CA Redwood City
- Assignee: GUARDANT HEALTH, INC.
- Current Assignee: GUARDANT HEALTH, INC.
- Current Assignee Address: US CA Redwood City
- Agent Indhu Kanakaraj
- Main IPC: C12Q1/6886
- IPC: C12Q1/6886 ; G16B30/00 ; C12Q1/6809 ; G16B99/00 ; G16B30/10 ; G16B20/10 ; C12Q1/6874
Abstract:
Methods are provided herein to improve automatic detection of copy number variation in nucleic acid samples. These methods provide improved approaches for determining baseline copy number of genetic loci within a sample, reduce variation due to features of genetic loci, sample preparation, and probe exhaustion.
Information query
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