Invention Grant
- Patent Title: Crystal forms of demethyleneberberine hydrochloride and preparation method therefor
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Application No.: US16960810Application Date: 2018-07-12
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Publication No.: US11242340B2Publication Date: 2022-02-08
- Inventor: Yubin Zhang , Yuanqiang Zhang , Miao Zhang , Qingxia Li
- Applicant: China Pharmaceutical University
- Applicant Address: CN Jiangsu
- Assignee: China Pharmaceutical University
- Current Assignee: China Pharmaceutical University
- Current Assignee Address: CN Jiangsu
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: CN201810115491.2 20180206
- International Application: PCT/CN2018/095341 WO 20180712
- International Announcement: WO2019/153644 WO 20190815
- Main IPC: C07D455/03
- IPC: C07D455/03 ; A61K31/4745 ; A61P9/10 ; A61P3/06

Abstract:
Provided are four crystal forms, A, B, C and D, of demethyleneberberine hydrochloride, and a preparation method therefor, and further provided are X-ray powder diffraction characteristic absorption peaks, infrared absorption peaks and DSC spectra of the four crystal forms. The X-ray powder diffraction characteristic diffraction peaks of the crystal forms are at about 8.205°, 8.805°, 10.817°, 14.835°, 15.479°, 16.668°, 17.492°, 18.529°, 20.656°, 21.536°, 23.538°, 25.657°, 26.192°, and 28.808°. A preparation method for the four crystal forms of the demethyleneberberine hydrochloride is also involved. The preparation method has a simple process, a high yield and a low cost; and has a high product purity and a stable quality.
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