Invention Grant
- Patent Title: Oxadiazole linkers and use thereof
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Application No.: US16629885Application Date: 2018-06-04
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Publication No.: US11241503B2Publication Date: 2022-02-08
- Inventor: Nianhe Han , Deqiang An , Di Zeng , Baoxiang Wang , Huali Li , Hang Chen , Chun Yang
- Applicant: NewBio Therapeutics, Inc.
- Applicant Address: CN Shanghai
- Assignee: NewBio Therapeutics, Inc.
- Current Assignee: NewBio Therapeutics, Inc.
- Current Assignee Address: CN Shanghai
- Agency: Edell, Shapiro & Finnan, LLC
- Priority: CN201710556847.1 20170710
- International Application: PCT/CN2018/089767 WO 20180604
- International Announcement: WO2019/011078 WO 20190117
- Main IPC: A61K47/68
- IPC: A61K47/68 ; C07D271/113 ; C07K16/32
Abstract:
The present invention is directed to oxadiazole linkers and use thereof, more specifically to the compounds represented by formula I, II, and III, and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from said oxadiazole linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I, II, and III is the same as that in the description.
Public/Granted literature
- US20210154320A1 OXADIAZOLE LINKERS AND USE THEREOF Public/Granted day:2021-05-27
Information query
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