Interference on an uplink between user equipment (UE) and a network site can disrupt the communications between the two. An interference mitigation tool can mitigate the effects such interference has on the communications between the UE and the network site by selecting a mitigation action for implementation at the network site. The interference mitigation tool can receive spectrum scan data from the network site to identify the presence of interference in an operating band of the network site. The interference mitigation tool can then determine possible mitigation actions and can select a mitigation action based on a variety of factors or criteria. Additionally, the interference mitigation tool can reverse previously implemented mitigation actions if the interference is no longer impacting the network site. Further, when selecting a mitigation action, the interference mitigation tool can also consider neighboring network sites and how the selected mitigation action would impact them.