Method, device, and system for deriving keys are provided in the field of mobile communications technologies. The method for deriving keys may be used, for example, in a handover process of a User Equipment (UE) from an Evolved Universal Terrestrial Radio Access Network (EUTRAN) to a Universal Terrestrial Radio Access Network (UTRAN). If a failure occurred in a first handover, the method ensures that the key derived by a source Mobility Management Entity (MME) for a second handover process of the UE is different from the key derived for the first handover process of the UE. This is done by changing input parameters used in the key derivation, so as to prevent the situation in the prior art that once the key used on one Radio Network Controller (RNC) is obtained, the keys on other RNCs can be derived accordingly, thereby enhancing the network security.