A method of joint encoding schemes with interleaver and tone mapper for multiple-resource unit (multi-RU) operation involves performing joint encoding of a plurality of information bits to generate a plurality of encoded bit sequences. The method also involves processing the plurality of encoded bit sequences by interleaving and tone mapping the encoded bit sequences with respect to a plurality of resource units (RUs) on either or both of an aggregate-RU basis and an individual-RU basis to generate a plurality of processed bit sequences. The method further involves transmitting the plurality of processed bit sequences over the plurality of RUs.