Described herein are methods and systems for filling a medical prescription. One implementation comprises a central prescription handling engine comprising a server and a database, which is in communication with a computing device of a given user via a wide-area network and configured to receive prescription data corresponding to the medical prescription. The central prescription handling engine selectively routes the received prescription data to a given pharmacy interface among a plurality of pharmacy interfaces and selectively routes scheduling data received at the given pharmacy interface for communication to the given user. The given pharmacy interface is in communication with the central prescription handling engine and is configured to receive the prescription data from the central prescription handling engine and to communicate to the central prescription handling engine the scheduling data corresponding to the prescription data.